AUTHOR=Ren Zhexin , Yang Fei , Yao Sijia , Bi Lijun , Jiang Guanqin , Huang Ju , Tang Yunping 

TITLE=Effects of low molecular weight peptides from monkfish (Lophius litulon) roe on immune response in immunosuppressed mice

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.929105

DOI=10.3389/fnut.2022.929105

ISSN=2296-861X

ABSTRACT=In this study, the immunomodulatory activation of low-molecular-weight peptides from monkfish (Lophius litulon) roe (named MRP) on cyclophosphamide (CTX)-induced immunosuppressed mice was investigated. Our results indicated that MRP (100 mg/kg/d BW) could significantly increase the mice’s body weight and immune organ index, improving the morphological changes in the spleen and thymus, enhancing the serum levels of interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, immunoglobulin (Ig) A, IgM, and IgG. Furthermore, MRP could improve CTX-induced oxidative stress, and activate the NF-κB and MAPK pathways in the spleen tissues. Our study indicated that MRP has good immunomodulatory activation toward immunosuppressed mice, and it shows potential to be developed as an immune adjuvant or functional food.