AUTHOR=Yu Pengkui , Yu Lin , Lu Yi 

TITLE=Dietary consumption of cruciferous vegetables and bladder cancer risk: A systematic review and meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.944451

DOI=10.3389/fnut.2022.944451

ISSN=2296-861X

ABSTRACT=Objective: Previous studies on the association of cruciferous vegetables intake with bladder cancer risk have reported inconsistent results. We performed the present meta-analysis to summarize evidence on this association and to quantify the potential dose-response relation based on all available cohort studies. 

Methods: A comprehensive literature search of relevant articles up to March 2022 was performed in PubMed and EMBASE. The summary risk estimates with 95% confidence intervals for the highest versus the lowest intake of cruciferous vegetables were calculated. Dose-response meta-analysis was also performed for studies reporting categorical risk estimates for at least three quantitative levels of cruciferous vegetables intake. 

Results: We found that the highest cruciferous vegetables intake was not significantly associated with a lower risk of bladder cancer, compared with the lowest cruciferous vegetables intake category (RR=0.92, 95% CI 0.80-1.06). Linear dose-response meta-analysis indicated that the pooled RRs for 10 g/day or 1 servings/week increment of cruciferous vegetables intake was not significantly associated with a reduced risk of bladder cancer (P=0.106 and P=0.147, respectively). There was no evidence of significant publication bias either with Begg’s test (P =0.386) or Egger’s test (P=0.253).
 
Conclusion: The results of this study did not support the hypothesis that dietary cruciferous vegetables intake was associated with a lower risk of bladder cancer. Further large prospective cohort studies are warranted to confirm our preliminary findings.