AUTHOR=Lei Li , Liang Hongbin , Qu Yali , Zhong Qianhong , Zhang Qiuxia , Dai Lei , Lu Junyan , Xiao Min , Zhao Zhimeng , Zhou Fengyun , Li Yun , Hu Guifang , Xiu Jiancheng , Zhang Xinlu 

TITLE=Association between triglyceride-glucose index and worsening renal function in the elderly

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.951564

DOI=10.3389/fnut.2022.951564

ISSN=2296-861X

ABSTRACT=Background: Triglyceride-glucose (TyG) index is a simple marker of insulin resistance. However, insufficient data was available on whether TyG index is associated with worsening renal function (WRF) in the elderly. Therefore, this study was designed to explored the association between TyG index and WRF based on a community elderly cohort.
Methods: In this study, 7,822 elderly (aged ≥ 65 years) adults from southern China were enrolled and divided into 4 groups according to the TyG index quartiles. The primary endpoint was incident chronic kidney disease (CKD), defined as incident estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2. Additional endpoints included decline in eGFR of 30% and of 40% during follow-up period. 
Results: During the median 2.04 years follow-up period, 1,541 (19.7%) participants developed CKD. After adjusting for confounding factors, multivariable Cox regression models revealed significant associations between TyG index and incident CKD (HR per SD increase, 1.21, 95% CI: 1.14-1.29), decline in eGFR of 30% (HR per SD increase, 1.38; 95% CI: 1.26-1.50), and decline in eGFR of 40% (HR per SD increase, 1.42; 95% CI: 1.24-1.63). Furthermore, compared with those in Q1, participants in the Q4 demonstrated a higher risk of developing CKD (HR, 1.59; 95% CI: 1.35-1.88). These positive associations remain consistent across different subgroup populations. 
Conclusion: Our study suggested a positive and independent association between TyG index and WRF in the elderly.