AUTHOR=Fatima Urooj , Roy Sonam , Ahmad Shahnawaz , Ali Sabeeha , Elkady Wafaa M. , Khan Ilyas , Alsaffar Rana M. , Adnan Mohd , Islam Asimul , Hassan Md. Imtaiyaz 

TITLE=Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.972379

DOI=10.3389/fnut.2022.972379

ISSN=2296-861X

ABSTRACT=Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmaco-logical application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the un-derlying   molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic   potential in cognition and neuroprotection. Overall, this review provides deeper in-sights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects.