AUTHOR=Wang Yuan , Wang Jin-song , Dong Er-wei , Liu Qiu-xia , Wang Li-ge , Chen Er-ying , Jiao Xiao-yan , Diao Xian-min TITLE=Foxtail millet [Setaria italica (L.) P. Beauv.] grown under nitrogen deficiency exhibits a lower folate contents JOURNAL=Frontiers in Nutrition VOLUME=Volume 10 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1035739 DOI=10.3389/fnut.2023.1035739 ISSN=2296-861X ABSTRACT=Foxtail millet, a rich source of folates, is cultivated on infertile lands, for which N deficiency is the major issue. Environments have a significant influence on cereal folate levels. It is unknown whether N deficiency modulates folate levels. We investigated folate derivatives of 29 diverse foxtail millet cultivars under two N regimes (0 and 150 kg N ha-1) for two years to explore folate potential grown under low N. N deficiency reduced the contents of total folate and most derivatives. N affected folate content stronger than that of the cultivar genotype. Folate content of enriched folate cultivars was reduced by N deficiency obviously. Structural equation models (SEMs) revealed that N fertilization had a positive indirect effect on grain folate through influencing plant N and K accumulation, which indicated much attention should be paid to N management when foxtail millet was cultivated in infertile soil, to ensure foxtail millet folate contents.