AUTHOR=Wu Jiaxiang , Ding Ping’an , Wu Haotian , Yang Peigang , Guo Honghai , Tian Yuan , Meng Lingjiao , Zhao Qun 

TITLE=Sarcopenia: Molecular regulatory network for loss of muscle mass and function

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1037200

DOI=10.3389/fnut.2023.1037200

ISSN=2296-861X

ABSTRACT=Skeletal muscle provides the basis for human function and plays a key role in motor and energy metabolism. Sarcopenia is characterized by progressive and systemic skeletal muscle disease, involving degenerative loss of muscle mass, strength and function. Therefore, sarcopenia results in debilitating physical weakness, functional disability, falls, morbidity, loss of independence, and death, which reduces the quality of life of patients. In recent years, sarcopenia has become the focus of in-depth research. Some molecular mechanisms have been described as the cause of sarcopenia, involving very different levels of muscle physiology. These mechanisms cover neuromuscular junction lesion, imbalance of protein synthesis and breakdown, satellite cells dysfunction, etc. In this review, we summarize the current view on molecular causes of sarcopenia development, in order to provide new ideas for future researchers to find valuable therapeutic targets and develop relevant prevention strategies.