AUTHOR=Wuni Ramatu , Ventura Eduard F. , Curi-Quinto Katherine , Murray Claudia , Nunes Richard , Lovegrove Julie A. , Penny Mary , Favara Marta , Sanchez Alan , Vimaleswaran Karani Santhanakrishnan 

TITLE=Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1067033

DOI=10.3389/fnut.2023.1067033

ISSN=2296-861X

ABSTRACT=The prevalence of cardiometabolic diseases has increased in Latin American and the Caribbean populations (LACP). To identify gene-lifestyle interactions that modify the risk of cardiometabolic diseases in LACP, a systematic search using 11 search engines was conducted up to May 2022. Eligible studies were observational and interventional studies in either English, Spanish, or Portuguese. A total of 26,171 publications were screened for title and abstract; of these, 101 potential studies were evaluated for eligibility, and 74 articles were included in this study following full-text screening and risk of bias assessment. We identified 122 significant interactions between genetic and lifestyle factors on cardiometabolic traits and the vast majority of studies come from Brazil (29), Mexico (15) and Costa Rica (12) with FTO, APOE, and TCF7L2 being the most studied genes. The results indicate that 27 out of 33 LACP have not conducted studies yet, suggesting effects which are population-, gender-, and ethnic-specific. Only five studies were undertaken in low-socioeconomic settings, and most studies were cross-sectional, requiring a more thorough examination of the life-style factors. Most of the gene-lifestyle interactions were conducted once, necessitating replication to reinforce these results. Future gene-lifestyle interaction studies will need to replicate primary re-search of already studied genetic variants to enable comparison, and to explore the interactions between genetic and other lifestyle factors such as those conditioned by socioeconomic factors and the built environment. The protocol has been registered on PROSPERO, number CRD42022308488.