AUTHOR=Liu Zhongwei , Hu Yi , Wang Yuhan , Xu Baiwei , Zhao Jiangyue , Yu Ziyan 

TITLE=Relationship between high dose intake of vitamin B12 and glaucoma: Evidence from NHANES 2005–2008 among United States adults

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1130032

DOI=10.3389/fnut.2023.1130032

ISSN=2296-861X

ABSTRACT=Glaucoma has currently become the second leading cause of blindness in the world. Serum vitamin B12 level has been found to be involved in the development and progression of glaucoma. We performed the present study to confirm this association. We analyzed associations between vitamin intakes and glaucoma, using data from NHANES 2005-2008. Glaucoma diagnosis by fundus imaging was utilized. After screening, 594 subjects were finally included. Among all vitamin intakes, we observed significant differences between the two groups for vitamin B12 intake (5.93vs. 4.77 mg, p=0.033). According to the logistic regression results, the intake of vitamin B12 was significantly positively associated with glaucoma (model 1: OR = 1.078, 95%CI = 1.019~1.141; model 2: OR = 1.092, 95% CI = 1.031~1.158; model 3: OR = 1.092, 95% CI = 1.029~1.158). After performing a quantile regression, we observed a significant positive association between vitamin B12 intake and incident glaucoma in the fourth quartile (model 1: OR = 1.133, 95%CI = 1.060~1.210; model 2: OR = 1.141, 95% CI = 1.072~1.215; model 3: OR = 1.146, 95% CI = 1.071~1.226). Therefore, the above results, high-dose intake of vitamin B12 may promote the development of glaucoma.