AUTHOR=Kallur Ranjith Kumar , Madapati Sreenadh , Mathur Ankita , Bhattacharya Sourish 

TITLE=The role of Weizmannia (Bacillus) coagulans LMG S-31876 in treating IBS-diarrhea

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1310462

DOI=10.3389/fnut.2023.1310462

ISSN=2296-861X

ABSTRACT=Irritable bowel syndrome (IBS) is a common gastrointestinal condition. Some studies have shown the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS).Weizmannia (Bacillus) coagulans LMG S-31876 has been marketed as a dietary ingredient, but its efficacy in diarrhea predominant irritable bowel syndrome (IBS) condition has not been clinically elucidated till date. Thus, a double blind placebo controlled multi-centered trial was planned to evaluate the safety and efficacy of Weizmannia (Bacillus) coagulans LMG S-31876 in diarrhea predominant IBS patients.Experimental Design: Subjects (n=50) diagnosed with IBS prominent symptoms that include abdominal pain and other GI-related symptoms were treated with ProBC Plus (2 billion CFU) along with a placebo capsule once daily for about 8 weeks. Subjects were evaluated for the treatment success determined by the differences in stool consistency and frequency per day between the intervention and placebo groups over the study period.The vitals and the biochemistry parameters were under the normal range, the other parameters showed a significant result as compared to the placebo during the study period.The present study depicts a significant decline in the clinical symptoms such as abdominal pain, bloating, diarrhea and frequency of the stool as compared to the placebo. All the parameters such as hematology, lipid profile and vitals were in the normal range during the supplementation of ProBC Plus for a period of 8 weeks. Further, the study verified that Weizmannia (Bacillus) coagulans LMG S-31876 and its probiotic product ProBC Plus at a dose of 2 billion/cfu/day has a prominent action in the relief from the clinical symptoms of IBS-D.Thereby, the product is intended safe to utilize for IBS-related symptoms.