AUTHOR=Zhong Lei , Liu Jifeng , Xia Mingquan , Zhang Yunshu , Liu Shuo , Tan Guang 

TITLE=Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 10 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1315097

DOI=10.3389/fnut.2023.1315097

ISSN=2296-861X

ABSTRACT=Background: Numerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.Methods: PubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger's linear regression test and a funnel plot.Results: Fifteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.64, 95% CI 1.48-1.81; multivariate analysis: HR 1.69; 95% CI 1.39-2.05, I 2 =77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (univariate analysis: HR 1.74, 95% CI 1.47-2.05; 1.54; 95% CI 1.23-1.93, I 2 =14.2%).Conclusions: Sarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.