AUTHOR=Liu Yang , Fan Linlin , Yang Haoying , Wang Danli , Liu Runhan , Shan Tikun , Xia Xue 

TITLE=Ketogenic therapy towards precision medicine for brain diseases

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1266690

DOI=10.3389/fnut.2024.1266690

ISSN=2296-861X

ABSTRACT=Precision nutrition and nutrigenomics emerge in therapeutic development for multiple diseases. The ketogenic diet (KD) is the most practiced clinical diet, providing high-fat, low-carbohydrate, and adequate protein. KD produces ketones and alters the metabolism of patients. Growing evidence suggests that KD has therapeutic effects over a broad spectrum of neuronal diseases including epilepsy, neurodegeneration, cancer, and metabolic disorders. Although KD is considered a low-side-effect diet treatment, its therapeutic mechanism has not yet been fully disclosed. Also, its induced keto-response among different populations has not been elucidated. Understanding the ketone metabolism in health and disease is critical for KD-associated therapeutics development and synergistic therapy under any physiological background. Here, we review the current advances and known heterogeneity of KD response and discuss the perspective for KD therapy under a precision nutrition aspect.