AUTHOR=Zhang Yi , Zhou Jingxin , Shen Wenyue , Grzybowski Andrzej , Jin Kai , Ye Juan TITLE=Association between dietary inflammation index and cataract: a population-based study from NHANES 2005–2008 JOURNAL=Frontiers in Nutrition VOLUME=Volume 11 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1379317 DOI=10.3389/fnut.2024.1379317 ISSN=2296-861X ABSTRACT=The Dietary Inflammation Index (DII), a measure reflecting the inflammatory potential of diets as proposed by the Dietary Guidelines for Americans, has demonstrated protective effects against various diseases. Various studies have widely explored the association between index of dietary inflammation (DII) and occurrence of diseases. Accumulating evidence have revealed that a lower DII seems to be protective against a variety of diseases. Nevertheless, the association between DII and age-related cataract remains unclear.Objective: To investigate the correlation between DII and age-related cataract in a representative sample of the American population.Design, setting, and participants: This cross-sectional population-based study comprised 6395 participants from the National Health and Nutrition Examination Survey (NHANES) conducted in cycles from 2005 to 2008. DII was calculated using dietary recall information, with higher scores indicating greater inflammatory potential of the diet. ranging from 0 to 100, with higher scores indicating a healthier diet. Age-related cataract was evaluated using cataract surgery as a surrogate measure. Covariates included sociodemographic factors, lifestyle factors, physical measures, and comorbidities. Logistic regression models were employed to assess the association between DII and cataract. The presence of a non-linear relationship was examined using restricted cubic spline analysis. Subgroup analysis was conducted to explore potential interaction effects. Data analysis was performed from September 1 to December 30, 2022.