AUTHOR=Gao Linxiao , Fang Haoyu , Zhao Zhibo , Luo Wen , Gong Jianping , Gong Junhua 

TITLE=Synergistic impact of Composite Dietary Antioxidant Index and physical activity on fatty liver disease

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1486700

DOI=10.3389/fnut.2024.1486700

ISSN=2296-861X

ABSTRACT=Background: The relationship between dietary antioxidants and fatty liver disease remains a topic of debate. This study aimed to examine the association between the Composite Dietary Antioxidant Index (CDAI) and nonalcoholic fatty liver disease (NAFLD) / metabolic-associated fatty liver disease (MAFLD). 
Methods: The study analyzed data from the 2003-2018 cycles of the National Health and Nutrition Examination Survey. The study included 16,321 individuals aged 20 to 85 years. Food and nutrient intake data were based on the 24-hour recall method. Multivariate logistic regression models were employed to examine the relationship between CDAI and NAFLD/MAFLD. 
Results: In the fully adjusted multivariate logistic regression model, CDAI demonstrated a significant negative correlation with NAFLD and MAFLD. Mediation analysis showed that inflammatory factors partially mediated the relationship between CDAI and NAFLD/MAFLD prevalence. The combination of high CDAI levels with effective physical activity was associated with a greater reduction in NAFLD/MAFLD prevalence than high CDAI levels alone.
Conclusions: Our study highlighted a negative association between CDAI and NAFLD/MAFLD, mediated by inflammatory factors. Additionally, participants with characteristics of active physical activity and high levels of CDAI were more strongly correlated with the reduced prevalence of NAFLD/MAFLD. Further research in clinical cohorts should be conducted to comprehensively investigate the impact of CDAI on NAFLD/MAFLD prevalence.