AUTHOR=Fornari Laurindo Lucas , Fornari Laurindo Lívia , Dogani Rodrigues Victória , da Silva Camarinha Oliveira Jéssica , Leme Boaro Beatriz , Cressoni Araújo Adriano , Landgraf Guiguer Elen , Rucco Penteado Detregiachi Claudia , Maria Cavallari Strozze Catharin Virgínia , Federighi Baisi Chagas Eduardo , Cavallari Strozze Catharin Vitor , Direito Rosa , Barbalho Sandra Maria 

TITLE=Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1502815

DOI=10.3389/fnut.2025.1502815

ISSN=2296-861X

ABSTRACT=Diabetes mellitus and dyslipidemia are significant health concerns that elevate the risk of cardiovascular disease and other metabolic disorders, necessitating effective management strategies. Recent research has highlighted the potential role of dietary fats, particularly seed oils, in influencing health outcomes in these conditions. This systematic review evaluates the impact of seed oils on lipid profiles, inflammatory and oxidative markers, and glycemic control in patients with diabetes and dyslipidemia. A comprehensive search across databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, identified studies focusing on the effects of seed oils. The studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and open-label studies published in English. The quality of the studies was assessed through a detailed review process, and data were extracted to evaluate the effects of seed oils on key metabolic markers. The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers. The findings suggest that seed oils may benefit in managing diabetes and dyslipidemia, although the results are sometimes inconsistent. This review provides valuable insights for dietary recommendations and therapeutic strategies, highlighting the need for further research to clarify the role of seed oils in metabolic health.