AUTHOR=Huang Jun , Zhang Yulan , Wu Chao , Wu Yifan , Wang Feiran , Ning Yunxuan , Shi Lu 

TITLE=Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1528114

DOI=10.3389/fnut.2025.1528114

ISSN=2296-861X

ABSTRACT=ObjectiveTo investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.MethodsUsing data from the National Health and Nutrition Examination Survey (2005–2008), we analyzed 2,615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors. Glaucoma was identified through self-reported diagnosis and retinal imaging. Survey-weighted logistic regression and restricted cubic splines (RCS) were used to assess associations.ResultsHigher OBS was associated with lower glaucoma risk (adjusted OR = 0.97, 95% CI: 0.94–1.00). Participants in the highest OBS quartile showed 51% lower odds of glaucoma compared to the lowest quartile (adjusted OR = 0.49, 95% CI: 0.27–0.90). The protective effect was more pronounced among middle-aged adults (40–60 years; OR = 0.90, 95% CI: 0.86–0.95) and males (OR = 0.93, 95% CI: 0.90–0.97).ConclusionHigher OBS were associated with lower glaucoma prevalence, particularly among middle-aged adults and males, suggesting potential benefits of maintaining oxidative balance in glaucoma prevention.