AUTHOR=Yan Xinzhou , Shao Xianhua , Zeng Tengyue , Zhang Qijie , Deng Junpeng , Xie Jianjun 

TITLE=National analysis of the dietary index for gut microbiota and kidney stones: evidence from NHANES (2007–2018)

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1540688

DOI=10.3389/fnut.2025.1540688

ISSN=2296-861X

ABSTRACT=BackgroundPrevious studies have highlighted the effects of diet and gut microbiota on the incidence of kidney stones, and the dietary index for gut microbiota (DI-GM) is a new dietary index that accurately represents the variety of gut microbiota. The current study intends to examine the potential correlation between DI-GM and kidney stones.MethodsData from the 2007–2018 National Health and Nutrition Examination Survey (NHANES) were employed in this cross-sectional study. The history of kidney stones was assessed using a kidney conditions questionnaire. In order to examine the correlation between DI-GM and kidney stones, multivariate logistic regression was implemented. Additionally, smoothed curve fitting, subgroup analyses, and sensitivity analyses were conducted.ResultsThe investigation encompassed a total of 21,587 participants. After adjusting for all potential covariates, we found that DI-GM was negatively related to the incidence of kidney stones (OR = 0.96, 95% CI = 0.93–0.98, p = 0.0021). Compared to those in the lowest quartile, participants in the highest quartile had a lower prevalence of kidney stones (OR = 0.86, 95% CI = 0.75–0.98, p = 0.0252). Additionally, smoothed curve fitting revealed that DI-GM was linearly associated with the incidence of kidney stones. The results of the sensitivity analyses proved the robustness of the main analyses.ConclusionA negative correlation between the incidence of kidney stones and DI-GM is supported by the evidence presented in this study. This finding emphasizes the potential benefits of adjusting dietary structure according to DI-GM in reducing the incidence of kidney stones. Further research should validate this discovery by employing longitudinal studies.