AUTHOR=Murugesan Ria , Thiruselvam Shubhashree , Leela Kakithakara Vajravelu , Satheesan Abhishek , Geetha K. , Ram Mohan , Kumar Janardanan 

TITLE=Impact of a structured food sequence and mobile health monitoring on gestational diabetes outcomes: a clinical trial

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1562240

DOI=10.3389/fnut.2025.1562240

ISSN=2296-861X

ABSTRACT=BackgroundGestational Diabetes Mellitus (GDM) is a common pregnancy complication that poses risks to both mother and baby. Dietary management is crucial in controlling blood glucose, and recent evidence suggests that the order in which food is consumed (food sequencing) can improve glycemic control. Mobile health (mHealth) tools also offer promising support for healthier eating habits and glucose monitoring. This study evaluates whether combining a structured food sequence with mHealth monitoring enhances outcomes in women with GDM.MethodsFifty-four pregnant women diagnosed with GDM were randomized into an intervention group (n = 27) and a control group (n = 27). The intervention group followed a structured food order—fiber first, then protein, and carbohydrates last—and tracked their intake using a mobile health application (JotForm). The control group received standard antenatal care without food sequencing. Fasting and postprandial glucose, lipid profiles, hemoglobin, and pregnancy outcomes were measured at baseline, the end of the third trimester, and 4 weeks postpartum. Data analysis included paired and independent t-tests or non-parametric equivalents, with chi-square tests for categorical variables. A p-value <0.05 was considered statistically significant.ResultsThe intervention group showed significant reductions in 1-h and 2-h postprandial blood glucose levels (−8.41 mg/dL and −7.56 mg/dL respectively, both p < 0.001), decreased LDL cholesterol (−7.33 mg/dL, p < 0.001), increased HDL cholesterol (+6.15 mg/dL, p < 0.001), and improved hemoglobin levels. They also had more normal deliveries (13 vs. 10) and fewer cases of shoulder dystocia (2 vs. 5) compared to controls. Additionally, this group exhibited lower average birth weights, fewer NICU admissions, and reduced neonatal complications.ConclusionCombining a structured food sequencing approach with mHealth dietary monitoring improved maternal glycemic control and pregnancy outcomes in women with GDM. This strategy shows promise for supporting dietary adherence and managing GDM effectively, warranting further research to validate its broader application.Clinical trial registrationhttps://ctri.nic.in/Clinicaltrials/main1.php?EncHid=93509.81482, identifier CTRI/2024/01/061220.