AUTHOR=Dong Xiaoyu , Shi Hanhan , Zhang Sensen , Deng Xiaoying , Ge Yongchao , Li Yongchao TITLE=Impact of fermentation on the processing and digestion characteristics of honeysuckle polyphenols by Lactobacillus acidophilus JOURNAL=Frontiers in Nutrition VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1570648 DOI=10.3389/fnut.2025.1570648 ISSN=2296-861X ABSTRACT=The technology and digestive characteristics of honeysuckle beverages fermented by Lactobacillus acidophilus were researched, the digestive characteristics were evaluated by simulating the gastrointestinal digestive system in vitro. The optimum conditions were as follows: fermentation temperature, 35°C; fermentation time, 19 h; and inoculation amount, 3%. Fermented honeysuckle beverages had greater antioxidant and α-glucosidase inhibition capacities than unfermented beverages after digestion. The bioavailabilities of total phenol, total flavonoids and chlorogenic acid in fermented honeysuckle liquid were 29.72, 21.80, and 36.93%, respectively, whereas those in unfermented honeysuckle liquid were 22.03, 17.28, and 25.67%, respectively. The pH of the fermented honeysuckle beverage remained relatively stable during storage at 4°C, with no significant change (p > 0.05). The number of viable bacteria decreased from 9.79 lg CFU/mL to 8.31 lg CFU/mL, and the sensory score and color decreased. This study provides a reference basis for the development of honeysuckle products and specific functional probiotic products.