AUTHOR=Khan Umael , Brønstad Ingeborg , Hillestad Eline Margrete Randulff , Steinsvik Elisabeth K. , Hausken Trygve , Berentsen Birgitte , Lied Gülen Arslan 

TITLE=Increase in circulating GLP-1 following low FODMAP diet in irritable bowel syndrome patients

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1615671

DOI=10.3389/fnut.2025.1615671

ISSN=2296-861X

ABSTRACT=BackgroundFermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) as well as glucagon-like peptide-1 (GLP-1) have independently been implicated in irritable bowel syndrome (IBS) pathophysiology. However, there is a lack of studies that assess how low FODMAP diet affects circulating GLP-1 levels in IBS patients.MethodsThirty patients with either diarrhea or mixed type IBS were recruited and undertook low FODMAP diet for 12 weeks. Plasma GLP-1 levels, IBS Severity Scoring System (IBS-SSS), body weight and FODMAP intake were assessed before and after the 12-week dietary intervention.Key resultsFollowing a low FODMAP diet, average IBS-SSS and body weight were reduced (p < 0.01) and plasma GLP-1 level was increased (p = 0.027).ConclusionOur study indicates that a 12-week low FODMAP diet may increase plasma glucagon-like peptide-1 levels in IBS patients. The underlying mechanism for this increase remains to be understood.