AUTHOR=Torres-Méndez Jeimy Katherine , Rojo-López Marina Idalia , Antentas Maria , Vendrell Pau , Ortega Emilio , Alonso Nuria , Castelblanco Esmeralda , Muscarà Andrea , Rubinat Esther , Alcubierre Nuria , Hernández Marta , Rossell Joana , Granado-Casas Minerva , Mauricio Didac , Julve Josep 

TITLE=Association between dietary niacin intake and diabetic retinopathy in a Catalonian population: a cross-sectional study

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1626379

DOI=10.3389/fnut.2025.1626379

ISSN=2296-861X

ABSTRACT=BackgroundAccumulating evidence suggests that niacin interventions may have a beneficial role in preventing ophthalmological microangiopathic remodeling. This study aimed to assess the impact of niacin intake on the presence of diabetic retinopathy (DR) in two independent Mediterranean cohorts of individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D).MethodsCross-sectional, population-based epidemiologic study. A total of 243 individuals with T1D, and 291 individuals with T2D. All participants underwent an eye examination. Dietary niacin intake was analyzed using a validated Spanish 101-items food frequency questionnaire consumption. The association between niacin intake and DR was assessed using a multivariate logistic regression, with potential non-linear associations further explored through restricted cubic spline regression. DR diagnostic was established via multifield stereoscopic retinal photography, in accordance with the international consensus on DR.ResultsDR was identified in 103 out of 243 individuals with T1D and 144 out of 291 with T2D. Dietary niacin intake did not differ within the study groups according to DR status. Multivariate logistic regression models also revealed no association between dietary niacin intake and DR. As previously described, the duration of diabetes for T1D and T2D, [OR (95%CI), 1.02 (1.01–1.03), and 1.02 (1.02–1.03), respectively] and glycated hemoglobin (HbA1c) [OR (95%CI), 1.16 (1.09–1.24), and 1.14 (1.09–1.18), respectively] were identified as the main determinant variables for DR in both groups.ConclusionsWe found that dietary niacin intake was not associated with the presence of RD in subjects with either T1D or T2D. Further research is needed to better understand the potential role of niacin in the development or prevention of DR.