AUTHOR=Qin Zhuolin , Li Longqian , Hou Ming , Wang Cheng 

TITLE=The relationship between prognostic nutritional index and its components (albumin and lymphocyte count) and all-cause mortality in lung cancer patients: a hospital-based study with database external validation

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1649334

DOI=10.3389/fnut.2025.1649334

ISSN=2296-861X

ABSTRACT=ObjectiveThis study aimed to evaluate the prognostic value of the Prognostic Nutritional Index (PNI), derived from serum albumin and lymphocyte count, in predicting all-cause mortality among lung cancer patients, using both a hospital-based cohort and an external validation dataset.MethodsA hospital-based retrospective cohort study was conducted, supplemented with external validation using the NHANES database. Univariate and multivariate Cox proportional hazards regression analyses were performed to assess associations between PNI, its components, and mortality. Variance inflation factor (VIF) testing was used to evaluate multicollinearity. Kaplan–Meier (KM) curves and log-rank tests were employed to compare survival across PNI tertiles. Restricted cubic spline (RCS) models were applied to examine non-linear relationships between continuous variables and mortality risk.ResultsIn the hospital cohort, univariate Cox analysis revealed significant associations between PNI (HR = 0.89, 95% CI: 0.85–0.93, p < 0.01), albumin (HR = 0.88, 95% CI: 0.86–0.92, p < 0.01), lymphocyte count (HR = 0.60, 95% CI: 0.50–0.80, p < 0.01), and mortality. After multivariate adjustment and VIF testing (all VIF < 5), PNI remained an independent predictor of mortality. KM curves showed significant survival differences across PNI tertiles (log-rank p < 0.001). RCS analysis indicated a non-linear relationship between PNI and mortality risk (p for nonlinear = 0.007). External validation using NHANES data consistently supported the association between PNI and mortality, with significant survival differences in KM analysis (log-rank p = 0.011) and a non-linear trend in RCS.ConclusionPNI and its components—albumin and lymphocyte count—are significantly associated with all-cause mortality in lung cancer patients. PNI demonstrates promise as a practical and reproducible prognostic indicator, potentially aiding in risk stratification and clinical decision-making.