AUTHOR=Zhu Gongjian , Pan Dongsheng , Zheng Tongzhang , Lan Qing , Chen Xuezhong , Chen Yingtai , Kim Christopher , Bi Xiaofeng , Holford Theodore , Boyle Peter , Leaderer Brian , Chanock Stephen , Rothman Nathaniel , Zhang Yawei 

TITLE=Polymorphisms in Th1/Th2 Cytokine Genes, Hormone Replacement Therapy, and Risk of Non-Hodgkin Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 1 - 2011

YEAR=2011

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2011.00021

DOI=10.3389/fonc.2011.00021

ISSN=2234-943X

ABSTRACT=<p>We conducted a population-based case–control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between hormone replacement therapy (HRT) and risk of non-Hodgkin lymphoma (NHL). Compared to women without a history of HRT use, women with a history of HRT use had a significantly decreased risk of NHL if they carried <italic>IFNGR2</italic> (rs1059293) CT/TT genotypes (OR = 0.5, 95%CI: 0.3–0.9), <italic>IL13</italic> (rs20541) GG genotype (OR = 0.6, 95%CI: 0.4–0.9), and <italic>IL13</italic> (rs1295686) CC genotype (OR = 0.6, 95%CI: 0.4–0.8), but not among women who carried <italic>IFNGR2</italic> CC, <italic>IL13</italic> AG/AA, and <italic>IL13</italic>CT/TT genotypes. A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. A statistically significant interaction was observed for <italic>IFNGR2</italic> (rs1059293 <italic>P</italic><sub>for interaction</sub> = 0.024), <italic>IL13</italic>(rs20541 <italic>P</italic><sub><italic>f</italic>or interaction</sub> = 0.005), <italic>IL13</italic> (rs1295686 <italic>P</italic><sub>for interaction</sub> = 0.008), and <italic>IL15RA</italic> (rs2296135 <italic>P</italic><sub>for interaction</sub> = 0.049) for NHL overall; <italic>IL13</italic> (rs20541 <italic>P</italic><sub>for interaction</sub> = 0.0009), <italic>IL13</italic>(rs1295686 <italic>P</italic><sub>for interaction</sub> = 0.0002), and <italic>IL15RA</italic> (rs2296135 <italic>P</italic><sub>for interaction</sub> = 0.041) for B-cell lymphoma. The results suggest that common genetic variation in Th1/Th2 pathway genes may modify the association between HRT and NHL risk.</p>