AUTHOR=Leenders Gerald B., Tuszynski Jack A. TITLE=Stochastic and Deterministic Models of Cellular p53 Regulation JOURNAL=Frontiers in Oncology VOLUME=Volume 3 - 2013 YEAR=2013 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00064 DOI=10.3389/fonc.2013.00064 ISSN=2234-943X ABSTRACT=

The protein p53 is a key regulator of cellular response to a wide variety of stressors. In cancer cells inhibitory regulators of p53 such as MDM2 and MDMX proteins are often overexpressed. We apply in silico techniques to better understand the role and interactions of these proteins in a cell cycle process. Furthermore we investigate the role of stochasticity in determining system behavior. We have found that stochasticity is able to affect system behavior profoundly. We also derive a general result for the way in which initially synchronized oscillating stochastic systems will fall out of synchronization with each other.