AUTHOR=Liu Stephen V., Fabbri Muller , Gitlitz Barbara J., Laird-Offringa Ite A.

TITLE=Epigenetic Therapy in Lung Cancer

JOURNAL=Frontiers in Oncology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00135

DOI=10.3389/fonc.2013.00135

ISSN=2234-943X

ABSTRACT=<p>Epigenetic deregulation of gene function has been strongly implicated in carcinogenesis and is one of the mechanisms contributing to the development of lung cancer. The inherent reversibility of epigenetic alterations makes them viable therapeutic targets. Here, we review the therapeutic implications of epigenetic changes in lung cancer, and recent advances in therapeutic strategies targeting DNA methylation and histone acetylation.</p>