AUTHOR=Krebs Simone , Rodríguez-Cruz Tania G., DeRenzo Christopher , Gottschalk Stephen TITLE=Genetically Modified T Cells to Target Glioblastoma JOURNAL=Frontiers in Oncology VOLUME=3 YEAR=2013 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00322 DOI=10.3389/fonc.2013.00322 ISSN=2234-943X ABSTRACT=

Despite advances in surgical procedures, radiation, and chemotherapy the outcome for patients with glioblastoma (GBM) remains poor. While GBM cells express antigens that are potentially recognized by T cells, GBMs prevent the induction of GBM-specific immune responses by creating an immunosuppressive microenvironment. The advent of gene transfer has allowed the rapid generation of antigen-specific T cells as well as T cells with enhanced effector function. Here we review recent advances in the field of cell therapy with genetically modified T cells and how these advances might improve outcomes for patients with GBM in the future.