AUTHOR=Argyropulo-Palmer Miriam , Jenkins Aaron , Theti Davinder Singh , Larkin James , Montgomery David TITLE=Sunitinib in Metastatic Renal Cell Carcinoma: A Systematic Review of UK Real World Data JOURNAL=Frontiers in Oncology VOLUME=Volume 5 - 2015 YEAR=2015 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00195 DOI=10.3389/fonc.2015.00195 ISSN=2234-943X ABSTRACT=Background

Real world data (RWD) are increasingly used to inform drug reimbursement decisions, but it is unclear how well outcomes from real world studies compare to those of clinical trials. This systematic review seeks to compare outcomes for sunitinib in routine UK clinical practice with the sunitinib registrational and expanded-access program clinical trials.

Method

Systematic review of the real world published literature was undertaken. UK observational studies recording first- or second-line sunitinib efficacy were included. A qualitative summary of the results and comparison to the controlled clinical trials was conducted. Fifteen real world studies were included, 14 of which were only available as posters/presentations.

Results

Real world study reporting quality was generally low, making comparisons with the clinical trials difficult. Practice relating to starting dose, dose modification, timing of therapy initiation, and other factors varied between centers. Median progression-free survival and adverse events were generally comparable to the clinical trial outcomes, but overall survival was not.

Conclusion

There are few published data on sunitinib use in UK clinical practice. Studies are characterized by lack of peer reviewed publication and heterogeneity in design, reporting, and analysis. For use of RWD in the reimbursement setting, data collection and reporting will need to improve.

Highlights

There are few published data on sunitinib use in UK clinical practice.

Studies are characterized by lack of peer reviewed publication and heterogeneity in design, reporting, and analysis.

Practice varies considerably between different UK centers.

Median progression-free survival and adverse events are generally comparable to the clinical trial outcomes, but overall survival is not.

For use of real world data in the reimbursement setting, data collection and reporting will need to improve.