AUTHOR=Donaldson Marie , Owen Joshua L. , Chae Young K. , Choi Jennifer N. 

TITLE=Management of Persistent Pruritus and Lichenoid Reaction Secondary to Nivolumab With Narrowband Ultraviolet B Phototherapy

JOURNAL=Frontiers in Oncology

VOLUME=Volume 8 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00405

DOI=10.3389/fonc.2018.00405

ISSN=2234-943X

ABSTRACT=Immune checkpoint inhibitors targeting the programmed cell death receptor 1 (PD-1) are being increasingly utilized in the treatment of a variety of malignancies. The most common adverse events with anti-PD-1 therapy are cutaneous toxicities. We report the case of a 68-year-old man with stage IV non-small cell lung cancer treated with nivolumab who developed a severe lichenoid eruption that responded to systemic steroids, but was recalcitrant to steroid taper. The use of narrowband ultraviolet B phototherapy allowed for full resolution of the rash, cessation of systemic steroids, and continuation of nivolumab.