AUTHOR=Shao Ning , Wan Fangning , Abudurexiti Mierxiati , Wang Jun , Zhu Yao , Ye Dingwei 

TITLE=Causes of Death and Conditional Survival of Renal Cell Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 9 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00591

DOI=10.3389/fonc.2019.00591

ISSN=2234-943X

ABSTRACT=Background: As conditional survival could provide more relevant prognostic information at each follow-up time, the present study was to assess conditional overall survival (COS) based on two cohorts and assess the risks of death due to RCC vs. other causes. 
Methods: Fudan University Shanghai Cancer Center (FUSCC) and SEER database were used as the source of data for our analysis. COS and cancer-specific survival were evaluated using the Kaplan-Meier method. 
Results: A total of 90927 patients (SEER cohort = 88807, FUSCC cohort = 2120) were enrolled. Our results suggested that hazards of other causes-related death were always higher than that of cancer-specific death in low-risk RCC patients, but lower in metastatic RCC patients. It exceeded that of cancer-specific death by 8 years in high-risk RCC patients. Only in metastatic RCC patients, the COS improved markedly with survivorship increasing. After surviving 1, 2, 3, 4 and 5 years, the 5-years COS increased by +10, +18, +23, +29 and 35% (the observed 5-years OS: 12%), respectively. 
Conclusions: COS can better to help patients with metastatic RCC rather than other RCC patients. Additionally, COS brings optimism for metastatic RCC patients with expected poorer prognosis psychologically.