AUTHOR=Jamal Muhammad , Song Tianbao , Chen Bei , Faisal Muhammad , Hong Zixi , Xie Tian , Wu Yingjie , Pan Shan , Yin Qian , Shao Liang , Zhang Qiuping TITLE=Recent Progress on Circular RNA Research in Acute Myeloid Leukemia JOURNAL=Frontiers in Oncology VOLUME=Volume 9 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01108 DOI=10.3389/fonc.2019.01108 ISSN=2234-943X ABSTRACT=

Acute myeloid leukemia (AML) is a myeloid malignancy characterized by the proliferation of abnormal and immature myeloid blasts in the bone marrow. Circular RNA (circRNA) is a novel class of long non-coding RNA with a stable circular conformation that regulates various biological processes. The aberrant expression of circRNA and its impact on AML progression has been reported by a number of studies. Despite recent advances in circRNA research, our understanding of the leukemogenic mechanism of circRNA remains very limited, and translating the current circRNA-related research into clinical practice is challenging. This review provides an update on the functional roles of and research progress on circRNAs in AML with an emphasis on mechanistic insights. The challenges and opportunities associated with circRNA-based diagonostic and therapeutic development in AML are also outlined.