AUTHOR=Lin Xi-Jun , Liu Hui , Li Pei , Wang Hai-Feng , Yang An-Kui , Di Jin-Ming , Jiang Qi-Wei , Yang Yang , Huang Jia-Rong , Yuan Meng-Ling , Xing Zi-Hao , Wei Meng-Ning , Li Yao , Shi Zhi , Ye Jin 

TITLE=miR-936 Suppresses Cell Proliferation, Invasion, and Drug Resistance of Laryngeal Squamous Cell Carcinoma and Targets GPR78

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00060

DOI=10.3389/fonc.2020.00060

ISSN=2234-943X

ABSTRACT=MicroRNAs (miRs) play important roles in cancer. MiR-936 has been reported to suppress glioma and non-small cell lung cancer cell proliferation and invasion. However, the role of miR-936 in laryngeal squamous cell carcinoma (LSCC) is still unknown. In our present study, we have demonstrated that miR-936 was significantly downregulated in LSCC tissues compared with adjacent normal tissues. Furthermore, overexpression of miR-936 inhibited the proliferation, migration, invasion and drug resistance of LSCC cells. Moreover, miR-936 could improve the sensitivity of LSCC cells to doxorubicin and cisplatin. Additionally, GPR78 was identified as a novel target gene of miR-936 in LSCC cells. Overexpression of miR-936 significantly reduced the protein expression levels of GPR78 in LSCC cells. In summary, our study indicates that the miR-936/GPR78 axis could  be both a diagnostic marker and a therapeutic target for LSCC.