AUTHOR=Sundar Raghav , Smyth Elizabeth C. , Peng Siyu , Yeong Joe P. S. , Tan Patrick 

TITLE=Predictive Biomarkers of Immune Checkpoint Inhibition in Gastroesophageal Cancers

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00763

DOI=10.3389/fonc.2020.00763

ISSN=2234-943X

ABSTRACT=<p>Immune checkpoint inhibition has transformed cancer treatment. For gastroesophageal cancer, this class of drugs have demonstrated durable responses and survival benefit in a subgroup of patients, resulting in regulatory approval. However, several recent randomized phase III studies in gastroesophageal cancer have reported negative results, blunting initial enthusiasm. Identification and validation of predictive biomarkers with appropriate patient selection for benefit from immunotherapy is an area of intense research with novel concepts rapidly emerging. In this review we describe the latest immune checkpoint inhibitor trials which have been reported in gastroesophageal cancers with a focus on predictive biomarkers. We also explore novel biomarkers being developed to improve precision oncology for immunotherapy in gastroesophageal cancers.</p>