AUTHOR=Groot Koerkamp Maureen L. , Vasmel Jeanine E. , Russell Nicola S. , Shaitelman Simona F. , Anandadas Carmel N. , Currey Adam , Vesprini Danny , Keller Brian M. , De-Colle Chiara , Han Kathy , Braunstein Lior Z. , Mahmood Faisal , Lorenzen Ebbe L. , Philippens Marielle E. P. , Verkooijen Helena M. , Lagendijk Jan J. W. , Houweling Antonetta C. , van den Bongard H. J. G. Desiree , Kirby Anna M. 

TITLE=Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01107

DOI=10.3389/fonc.2020.01107

ISSN=2234-943X

ABSTRACT=Current research in radiotherapy for breast cancer is evaluating neoadjuvant as opposed to adjuvant
partial breast irradiation with the aim of reducing the volume of breast tissue irradiated and therefore
the risk of late treatment-related toxicity. The development of MR-guided radiotherapy, including
dedicated MR-guided radiotherapy systems (hybrid machines combining an MR-scanner with a
linear accelerator (MR-linac) or 60 Co sources) could potentially reduce the irradiated volume even
further by improving tumour visibility before and during each radiotherapy treatment. In this position
paper we discuss MR-guidance in relation to each step of the breast radiotherapy planning and
treatment pathway, focussing on the application of MR-guided radiotherapy to neoadjuvant partial
breast irradiation.