AUTHOR=Cao Guo-dong , He Xiao-bo , Sun Qiang , Chen Sihan , Wan Ke , Xu Xin , Feng Xudong , Li Peng-ping , Chen Bo , Xiong Mao-ming TITLE=RETRACTED: The Oncolytic Virus in Cancer Diagnosis and Treatment JOURNAL=Frontiers in Oncology VOLUME=10 YEAR=2020 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01786 DOI=10.3389/fonc.2020.01786 ISSN=2234-943X ABSTRACT=

Cancer has always been an enormous threat to human health and survival. Surgery, radiotherapy, and chemotherapy could improve the survival of cancer patients, but most patients with advanced cancer usually have a poor survival or could not afford the high cost of chemotherapy. The emergence of oncolytic viruses provided a new strategy for us to alleviate or even cure malignant tumors. An oncolytic virus can be described as a genetically engineered or naturally existing virus that can selectively replicate in cancer cells and then kill them without damaging the healthy cells. There have been many kinds of oncolytic viruses, such as herpes simplex virus, adenovirus, and Coxsackievirus. Moreover, they have different clinical applications in cancer treatment. This review focused on the clinical application of oncolytic virus and predicted the prospect by analyzing the advantages and disadvantages of oncolytic virotherapy.