AUTHOR=Zhang Runjiao , Dong Li , Yu Jinpu 

TITLE=Concomitant Pathogenic Mutations and Fusions of Driver Oncogenes in Tumors

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.544579

DOI=10.3389/fonc.2020.544579

ISSN=2234-943X

ABSTRACT=Gene alterations have always been one of the leading causes in the process of occurrence and development of tumors. And the effects of driver oncogene alterations on tumorigenesis and progression of different kinds of tumors have been studied heatedly. And the roles that the driver oncogenes alterations play have been elucidated clearly in the previous studies. The phenomenon of concomitant driver oncogenes mutations and genes rearrangements has gained much concentration in the past two decades. And a growing number of studies reported this phenomenon, either coexistence or mutually exclusivity. Here we reviewed on the phenomenon of concomitant mutations in two common types of carcinomas - lung cancer and thyroid cancer, which have been studied relatively more detailed and more general compared with others.