AUTHOR=Tang Yanyan , Tang Rui , Tang Mengtian , Huang Ping , Liao Zhiqiang , Zhou Jumei , Zhou Lianqing , Su Min , Chen Pan , Jiang Jiarui , Hu Yingbin , Zhou Yujuan , Liao QianJin , Zeng Zhaoyang , Xiong Wei , Chen Junhong , Nie Shaolin 

TITLE=LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.604534

DOI=10.3389/fonc.2020.604534

ISSN=2234-943X

ABSTRACT=Colorectal cancer (CRC) is one of the most common cancer in the world. Recent studies have shown that Long non-coding RNA (lncRNA) involved in tumorigenesis and development in colorectal cancer. By constructing lncRNA differential expression profile, we screened from the gene chip that DNAJC3-AS1 is highly expressed in CRC tissues and is associated with poor prognosis in patients with CRC. We further proved through assays such as wound healing, colony formation, and CCK-8 that after interfering with DNAJC3-AS1 can reduce the proliferation, migration, and invasion of CRC cells. Mechanically, we found that DNAJC3-AS1 regulates fatty acid synthase to promote the progress of CRC via the EGFR/PI3K/AKT/NF-κB signaling pathway. Therefore, DNAJC3-AS1 may be a new target for the diagnosis and therapy of CRC.