AUTHOR=Albahde Mugahed Abdullah Hasan , Abdrakhimov Bulat , Li Guo-Qi , Zhou Xiaohu , Zhou Dongkai , Xu Hao , Qian Huixiao , Wang Weilin 

TITLE=The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.640863

DOI=10.3389/fonc.2021.640863

ISSN=2234-943X

ABSTRACT=Pancreatic cancer has extremely low prognosis, which is a direct result of its high aggressiveness and invasiveness as well as late diagnosis and lack of effective therapies. One of the most crucial drugs with highly optimistic clinical potential to join the fight against cancer are considered to be microtubule-targeting agents. Almost each type acts differently on cancer cells, but with one common and significant result, which is inhibition of cancer cells. We review here functions of microtubule cytoskeletal proteins in tumor cells and comprehensively examine effects of microtubule-targeting agents on pancreatic carcinoma.