AUTHOR=Dong Qiang , Li Qiao , Duan Lei , Yin Hang , Wang Xiaoqing , Liu Yang , Wang Bo , Li Kun , Yao Xuan , Yuan Guoqiang , Pan Yawen 

TITLE=Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.652008

DOI=10.3389/fonc.2021.652008

ISSN=2234-943X

ABSTRACT=Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether the effect of BCA on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecular mechanisms of BCA in GBM. We observed that BCA inhibited the growth of U251 cell by mitochondria-mediated intrinsic apoptotic pathway. BCA treatment reduced metabolic function, repressed mitochondrial membrane potential and increased the production of reactive oxygen species (ROS) in GBM. In addition, we found that BCA inhibited aerobic glycolysis by inactivation of AKT/mTOR pathway. Taken together, the results demonstrate that treatment with BCA inhibited proliferation of glioma by regulating metabolic reprogramming.