AUTHOR=Hai Rihan , He Liuer , Shu Guang , Yin Gang 

TITLE=Characterization of Histone Deacetylase Mechanisms in Cancer Development

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.700947

DOI=10.3389/fonc.2021.700947

ISSN=2234-943X

ABSTRACT=Over decades of studies, accumulating evidence suggests that epigenetic dysregulation serves as a tumor hallmark. Posttranslational modifications of histones participate in tumor pathogenesis and development mainly through influencing a broad range of physiological processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are pivotal epigenetic modulators, which regulate dynamic processes in the acetylation of histones at lysine residues, thereby influencing transcriptions of oncogenes and tumor suppressor genes. Moreover, HDACs mediate the deacetylation process of many nonhistone proteins, while the latter orchestrate a host of pathological processes such as tumor pathogenesis. In this review, we elaborate on the function of HDACs function in cancer.