AUTHOR=Zhong Yunbin , Li Haibo , Li Peiwen , Chen Yong , Zhang Mengyao , Yuan Zhendong , Zhang Yufang , Xu Zhijie , Luo Geng , Fang Yuan , Li Xu 

TITLE=Exosomes: A New Pathway for Cancer Drug Resistance

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.743556

DOI=10.3389/fonc.2021.743556

ISSN=2234-943X

ABSTRACT=Exosomes are extracellular vesicles (EVs) that are secreted by multiple cell types into body fluids. The exosomes are enriched in bioactive molecules, although their exact contents depend on the parental cells. Studies show that exosomes in the tumor microenvironment affect tumor growth, metastasis and drug resistance by mediating intercellular communication and transport of specific molecules, although the exact mechanisms need to investigated further. In this review, we have summarized the current research on the relationship between tumor drug resistance and exosomes, and discussed the potential applications of exosomes as diagnostic biomarkers and therapeutic targets.