AUTHOR=Sun Yingxin , Cai Yifeng , Chen Jia , Cen Jiannong , Zhu Mingqing , Pan Jinlan , Wu Depei , Sun Aining , Chen Suning 

TITLE=Diagnosis and Treatment of Myeloproliferative Neoplasms With PCM1-JAK2 Rearrangement: Case Report and Literature Review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.753842

DOI=10.3389/fonc.2021.753842

ISSN=2234-943X

ABSTRACT=Myeloproliferative neoplasms (MPN) with PCM1-JAK2 rearrangement is rare disease with poor prognosis and lacks of uniform treatment guidelines. Several studies confirmed the efficacy of ruxolitinib in hematological malignancies with PCM1-JAK2 fusion, but the efficacy is variable. Here, we report two patients diagnosed with MPN with PCM1-JAK2 fusion, who were treated with ruxolitinib-based regimen, including the first case of ruxolitinib combined with pegylated interferon (Peg-IFN), and conduct a literature review. We found that ruxolitinib combined with Peg-IFN is an effective treatment option in the case of poor efficacy of ruxolitinib monotherapy.