AUTHOR=Ghafouri-Fard Soudeh , Khoshbakht Tayyebeh , Taheri Mohammad , Jamali Elena 

TITLE=A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.762960

DOI=10.3389/fonc.2021.762960

ISSN=2234-943X

ABSTRACT=CircPVT1 (hsa_circ_0001821) is a cancer-related circRNAs which is originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be up-regulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203 and miR-199a-5p. Moreover, it can regulate activity of PI3K/AKT, Wnt5a/Ror2, E2F2 and HIF-1α. Up-regulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo and clinical investigation.