AUTHOR=Li Wei , Shang Wenwen , Lu Feng , Sun Yuan , Tian Jun , Wu Yiman , Dong Anding 

TITLE=Diagnostic Performance of Extraprostatic Extension Grading System for Detection of Extraprostatic Extension in Prostate Cancer: A Diagnostic Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.792120

DOI=10.3389/fonc.2021.792120

ISSN=2234-943X

ABSTRACT=Purpose: To evaluate the diagnostic performance of the EPE grading system for detection of extraprostatic extension in patients with prostate cancer (PCa). 
Materials and Methods: We performed a literature search of Web of Science, MEDLINE (Ovid and PubMed), Cochrane Library, EMBASE, and Google Scholar to identify eligible articles published before August 31, 2021, with no language restrictions applied. We included studies using the EPE grading system for prediction of extraprostatic extension, with histopathological results as the reference standard. The pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR−), and diagnostic odds ratio (DOR) were calculated with the bivariate model. Quality assessment of included studies was performed using the Quality Assessment of Diagnostic Accuracy Studies–2 tool. 
Results: A total of 4 studies with 1294 patients were included in the current systematic review. The pooled sensitivity and specificity were 0.82 (95% CI 0.76-0.87) and 0.63 (95% CI 0.51-0.73), with area under hierarchical summary receiver operating characteristic (HSROC) curve of 0.82 (95% CI 0.79-0.85). The pooled LR+, LR−, and DOR were 2.20 (95% CI 1.70-2.86), 0.28 (95% CI 0.22-0.36), and 7.77 (95% CI 5.27-11.44), respectively. Quality assessment for included studies was high, and the Deeks funnel plot indicated that the possibility of publication bias was low (P=0.64).
Conclusion: The EPE grading system demonstrated high sensitivity and moderate specificity, with a good inter-reader agreement. However, this scoring system needs more studies to validate in clinical practice.