AUTHOR=Zhao Yuting , Qiu Pei , Yan Lutong , Li Shouyu , Yang Zejian , Zhang Huimin , He Jianjun , Zhou Can 

TITLE=Epidemiological trends of female breast and gynecologic cancers in adolescents and young adults in China from 1990 to 2019: Results from the Global Burden of Disease Study 2019

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1003710

DOI=10.3389/fonc.2022.1003710

ISSN=2234-943X

ABSTRACT=Background: Research on the incidence, mortality, and disability-adjusted life years (DALYs) of female breast and gynecologic cancers (FeBGCs) and the relevant risk factors for adolescents and young adults (AYAs) are valuable for policy-making in China. We aimed to estimate the incidence, deaths, and DALYs and predict epidemiological trends of FeBGCs among AYAs in China between 1990 and 2019.  
Methods: Data from the 2019 Global Burden of Disease (GBD) study between 1990 and 2019 in 195 countries and territories were retrieved. Data about the number of FeBGCs incident cases, deaths, DALYs, age-standardized rates (ASRs), and estimated annual percentage changes (EAPCs) were extracted. A comparative risk assessment framework was performed to estimate the risk factors attributable to breast cancer deaths and DALYs, and autoregressive integrated moving average (ARIMA) models were fitted for time series analysis to predict female cancer morbidity and mortality among Chinese AYAs until 2030.  
Results: In 2019, the Chinese FeBGCs increased to 61,038 cases in incidence, decreased to 8,944 cases in deaths, and 529,380 in DALYs among the AYAs. The estimated annual percentage change (EAPC) values were positive scores (>0) in ASIRs and negative scores (<0) in ASMR and ASDR. And In 2030, the incidence rate of FeBGCs would grow to 30.49 per 100,000 in China, while the mortality rate would maintain a steady state. Of the deaths and DALYs, diet high in red meat was the greatest contributor to breast cancer, while a high body-mass index (BMI) was the greatest contributor to cervical, ovarian, and uterine cancers. 
Conclusion: The increasing Chinese FeBGCs burden is mainly observed in the AYAs, non-red meat diet, and the control of body weight could reduce FeBGCs burden in China.