AUTHOR=Lv Tian-Run , Wang Ju-Mei , Ma Wen-Jie , Hu Ya-Fei , Dai Yu-Shi , Jin Yan-Wen , Li Fu-Yu 

TITLE=The consistencies and inconsistencies between distal cholangiocarcinoma and pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1042493

DOI=10.3389/fonc.2022.1042493

ISSN=2234-943X

ABSTRACT=Abstract
Objective: To evaluate the consistencies and inconsistencies between distal cholangiocarcinoma (DCCA ) and pancreatic ductal carcinoma (PDCA) regarding their biological features and long-term prognosis.
Methods: PubMed, the Cochrane Library and EMBASE were searched to find comparative studies between DCCA and PDCA. RevMan5.3 and Stata 13.0 software were used for the statistical analyses.
Results: 11 studies with 4698 patients with DCCA and 100629 patients with PDCA were identified. Pooled results indicated that patient with DCCA shared a significantly higher rate of preoperative jaundice (P=0.0003). Lymphatic metastasis (P<0.00001), vascular invasion (P<0.0001) and peri-neural invasion (P=0.005) were more frequently detected in patients with PDCA. After curative PD, a significantly higher R0 rate (P<0.0001) and a significantly smaller tumor size (P<0.00001) were detected in patients with DCCA. Patients with DCCA shared a more favorable OS (P<0.00001) as well as DFS (P=0.005) than patients with DCCA. However, postoperative morbidities (P=0.02), especially POPF (P<0.00001), were more frequently occurred in DCCA.
Conclusion: DCCA shared a more favorable tumor pathological features and long-term prognosis than PDCA. An early diagnosis was more frequently occurred in patients with DCCA. However, postoperative complications, especially POPF, were more frequently observed in patients with DCCA.