AUTHOR=Pla Clàudia , Solans Marta , Ameijide Alberto , Sanvisens Arantza , Carulla Marià , Rojas María Dolores , Alemán María Araceli , Sáez-Lloret Isabel , Díaz-del-Campo Cristina , Marcos-Navarro Ana Isabel , Sainz-de-Aja Leire , Aizpurua-Atxega Amaia , Lopez-de-Munain Arantza , Sánchez Maria-José , Perucha Josefina , Franch Paula , Chirlaque María-Dolores , Guevara Marcela , Galceran Jaume , Merino Susana , Marcos-Gragera Rafael ,  REDECAN working group , RM-G  , Puigdemont Montse , Vila Anna Vidal , AS  , Castillo-Bonilla Andrés , MC  , AA  , CP  , JG  , AL-d-M  , Sancho Patricia , Iruretagoyena María Luisa , Ramírez Cristina , SM  , García Virginia Menéndez , Camblor Marta Rodríguez , Castro Visitación de , Cruz Marta De La , Bidaurrazaga Joseba , Gregori Consol Sabater , Lloret Isabel Sáez , Batllés Ana Vizcaíno , Herrero Xavier Peñalver , CD-d-C  , AM  , Chillarón Rosario Jimenez , AA  , MDR  , Miguel Emilio De , Gabas María Carmen , MJS  , Chang-Chan Daysi Yoe-Ling , Barranco Miguel Rodríguez , Palacios María Isabel , Ramalle Enrique , Franch Paula , Armengol Patricia Ruiz , Contador Carmen Sánchez , MDC  , Gil Antonia Sánchez , Vaamonde Ricardo José , MG  , Ardanaz Eva , MAA  , Velázquez Leonor Olga , Marrero María Magdalena Ramos , Gutiérrez Pilar , Álamo Rufino , Estévez Lorena , Cañete Adela , Pardo Elena , Bonet Rafael Peris , Gregori Consol Sabater , Batllés Ana Vizcaino , Vich. Fernando Almela 

TITLE=Incidence and survival of lymphoid neoplasms in Spain, 2002-2013: A population-based study from the Spanish Network of Cancer Registries (REDECAN)

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1046307

DOI=10.3389/fonc.2022.1046307

ISSN=2234-943X

ABSTRACT=The aim of this study was to describe incidence, incidence trends and survival patterns of lymphoid neoplasms (LNs) and its subtypes in Spain in the period 2002-2013 using data from the Spanish Network of Cancer Registries (REDECAN). Data were extracted from 13 Spanish population-based cancer registries. LNs incident cases were codified using the International Classification of Diseases for Oncology, third edition (ICD-O-3) and grouped according to the WHO 2008 classification. Age-standardized incidence rates to the 2013 European standard population (ASIRe) were obtained. Poisson regression models were used to analyze trends in incidence. Observed survival (OS) was estimated by the Kaplan-Meier method and net survival (NS) by the Pohar-Perme method. Sex- and age-specific estimates of 5-year NS were calculated, as well as its changes according to two periods of diagnosis (2002-2007 and 2008-2013). LNs accounted for 69% (n=39,156) of all hematological malignancies (n=56,751) diagnosed during the period of study. Median age at diagnosis was 67 years (interquartile range (IQR) = 52-77). The overall ASIRe was 34.23 (95% confidence interval (CI): 33.89, 34.57) and showed a marked male predominance in almost all subtypes (global sex ratio = 1.45). During the study period, incidence trends of LNs remained stable (APC: 0.3; 95% CI: -0.1, 0.6), nevertheless some subtypes showed statistically significant variations, such as LNs NOS category (APC: -5.6; 95% CI: -6.8, -4.3). Around 17,926 new cases of LNs will be diagnosed in 2023 in Spain. Survival rates differed considerably across age-groups, while they were similar between men and women. Five- year NS was 62.81% (95% CI: 62.1, 63.52) for all LNs, and varied widely across LNs subtypes, ranging from 39.21% to 90.25%. NS for all LNs improved from the first period of diagnosis to the second one, being 61.57% (95% CI: 60.56, 62.61) in 2002-2007 and 64.17% (95% CI: 63.29, 65.07) in 2008-2013. This study presents the first complete and extensive population-based analysis of LNs incidence and survival in Spain. These population-based data provide relevant information to better understand the epidemiology of LNs in Southern Europe and it features some useful points for public health authorities and clinicians.