AUTHOR=Xiang Jiangxia , Jiang Mengmeng , Du Xing 

TITLE=The role of Hippo pathway in ferroptosis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1107505

DOI=10.3389/fonc.2022.1107505

ISSN=2234-943X

ABSTRACT=Hippo pathway is mainly composed of serine/threonine kinase MST1/2, LATS1/2 and transcriptional coactivator YAP, and is closely related to cell growth, survival, proliferation, migration, size control of tissues and organs, and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and antioxidant system. This article elaborated the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.