AUTHOR=Qiao Lili , Chen Yanfei , Liang Ning , Xie Jian , Deng Guodong , Chen Fangjie , Wang Xiaojuan , Liu Fengjun , Li Yupeng , Zhang Jiandong 

TITLE=Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.775238

DOI=10.3389/fonc.2022.775238

ISSN=2234-943X

ABSTRACT=Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Despite many potential mechanisms of EMT-related radioresistance being reported, an overall understanding of the relationship between EMT and radioresistance remains insufficient. In this review, we discuss the interplay between EMT and radioresistance involved in EMT-related mechanisms in regulating radioresistance, irradiation-mediated EMT program, and the intervention strategies to increase tumor radiosensitivity, aiming to improve radiotherapy efficiency and clinical outcomes of cancer patients.