AUTHOR=Xu Yaolin , Zhang Yueming , Han Siyang , Jin Dayong , Xu Xuefeng , Kuang Tiantao , Wu Wenchuan , Wang Dansong , Lou Wenhui 

TITLE=Prognostic Effect of Age in Resected Pancreatic Cancer Patients: A Propensity Score Matching Analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.789351

DOI=10.3389/fonc.2022.789351

ISSN=2234-943X

ABSTRACT=Background: While the elderly population account for an indispensable proportion in pancreatic ductal adenocarcinoma (PDAC), these patients are underrepresented in clinical trials. Whether surgery offered the same benefit for elderly patients as that for younger cohort and which factors affected long-term outcome of elderly population remained unclear.
Aims: This study aims to evaluate long-term prognosis of elderly PDAC patients (≥70 years old) after surgery and to investigate potential prognostic factors .
Methods: This retrospective study included PDAC patients receiving radical resection from January 2012 to July 2019 in Zhongshan Hospital Fudan University. Patients were divided into young (<70) and old group (≥70). Propensity score matching (PSM) was conducted to eliminate the confounding factors. We investigated potential prognostic factors via C   ox proportional hazards model and Kaplan–Meier estimator. Nomogram model and forest plot were constructed to illustrate the prognostic value of age. 
Results: A total of 552 PDAC patients received radical resection were included in this research. Elderly patients showed poorer nutritional status and were less likely to received adjuvant treatment. After matching, elderly patients were associated with worse OS when compared with younger patients (p-value=0.039). Although it was statistically insignificant, Cox regression analyses still demonstrated negative prognostic effect of age (p-value=0.083). Furthermore, reception of adjuvant chemotherapy was the only independent prognostic factor among elderly patients and could significantly improve OS. Subgroup analysis indicated that age had better prognostic value in PDAC patients with relative lower level of CA 19-9, AFP, CA125, without lymph node metastases and perineural invasion, and those with normal serum albumin and hemoglobin. A prognostic prediction model of OS was constructed and presented in nomogram.
Conclusion: 
The elderly PDAC patients were associated with worse OS survival after radical resection and the noticeable negative effect of age was observed among PDAC patients with better preoperative nutritional status and less aggressive tumor biology. Adjuvant chemotherapy was essential to improve survival outcome of elderly PDAC patients following radical resection.