AUTHOR=Cheng Jie , Lao Yao-Jia , Wang Qian , Huang Kai , Mou Juan-Li , Feng Jia-Hui , Hu Fan , Lin Meng-Lu , Lin Jun 

TITLE=Predicting Distant Metastasis in Young-Onset Colorectal Cancer After Surgery: A Retrospective Study

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.804038

DOI=10.3389/fonc.2022.804038

ISSN=2234-943X

ABSTRACT=Background: Although overall colorectal cancer (CRC) cases have been declining worldwide, there has been an increase in the incidence of the CRC among individuals younger than 50 years, which is associated with distant metastasis (DM) and poor prognosis.
Methods: Young-onset CRC patients postoperative were collected from the Surveillance, Epidemiology, and End Results (SEER) database between January 2010 and December 2015. Data from SEER database was divided into early stage and advanced stage according to whether chemoradiotherapy was recommended in the guidelines. Independent risk factors for DM were explored by using univariate and multivariate logistic regression. A predictive model was established and presented as nomogram in the training set of advanced stage. The model was internally verified in testing set and externally validated in a cohort of 145 patients from Zhongnan Hospital of Wuhan University. The accuracy, reliability, and clinical application value were assessed using the receiver operating characteristic curve (ROC), the area under the curve (AUC), calibration curve and decision curve analysis (DCA) respectively. Different risk subgroups of DM were classified according to the scores of the nomogram in the training set of advanced stage.
Results: 5,584 patients were eligible and enrolled in our study in which of 1,277 were in early stage and 4,307 in advanced stage. Preoperative CEA positive was  an independent predictor of DM in early stage. Multivariate logistic regression analysis showed that tumor size, degree of differentiation, T stage, N stage, preoperative CEA and whether radiation or chemotherapy performed were independent risk factors for DM (all, P＜0.05) in advanced stage. Great accuracies were achieved in our nomogram with AUC of 0.801 in training set, 0.811 in testing set and 0.791 in the validation cohort respectively. Calibration curves and DCA in internal validation and external validation both showed good stability and clinical utility values.
Conclusions: Preoperative CEA positive was a significant predictor of DM for young-onset CRC patients. A novel nomogram containing clinical and pathological features was established for predicting DM of advanced CRC in patients younger than 50 years old. This tool may help clinicians be early alert to DM and make better clinical treatment regimens.