AUTHOR=Li Qingling , Lan Ting , Xie Jian , Lu Youguang , Zheng Dali , Su Bohua 

TITLE=Integrin-Mediated Tumorigenesis and Its Therapeutic Applications

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.812480

DOI=10.3389/fonc.2022.812480

ISSN=2234-943X

ABSTRACT=Abstract: Integrins, are a family of adhesion molecule generally exist on the cell surface, and essential to regulate cell growth and its functions. As a bi-directional signaling molecule, it mediates cell-cell and cell-extracellular matrix interaction. The recognitions of its key roles in many human pathologies, including  autoimmunity, thrombosis and neoplasia, have revealed great potential as a therapeutic target. This paper focuses on the structure, activation, the role of integrins in tumorigenesis and progression, and advances of integrin-dependent tumor therapeutics in recent years. It is expected that by understanding function and signaling transmission will fully exploit potentialities of integrin emerging as a novel target for tumors.